Carnivorous genital infections caused by diabetes medicines

Carnivorous genital infections caused by diabetes medicines

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Life-threatening infection from diabetes medication?

Medications for people with type 2 diabetes can cause a dangerous infection that causes a carnivorous bacterium to infect the soft tissues in the genitals.

A recent investigation by the American Food and Drug Administration (FDA) showed that newer drugs for the treatment of type 2 diabetes can trigger dangerous side effects. For example, they can cause a carnivorous bacterium to affect the genital area. The results of the study were published in the English-language journal "Annals of Internal Medicine".

Life-threatening infection affects men more often

A newer medicine to treat type 2 diabetes can cause dangerous side effects. There appears to be a connection between so-called SGLT2 inhibitors and Fournier gangrene, an infection with dangerous carnivorous bacteria, the researchers explain. The potentially life-threatening infection is more common in men because it particularly affects the scrotum and penis, where there are many small wrinkles in which the bacteria can survive. The infection can also develop around the anus or occur in the perineum, the area between the anus and vulva or scrotum, the researchers explain. So are women from the disease.

What is a Fournier gangrene?

Fournier gangrene is a serious condition that quickly kills soft tissues, including muscles, nerves, and blood vessels. Early symptoms start within 24 hours of infection and often begin with a general feeling of being unwell.

Affected people may also notice pain or swelling in the genital area. These symptoms worsen, and bad odor develops when the tissue dies or rots. The infection is treated using antibiotics. In worse cases, surgery may even require removal of tissue, such as the entire penis and testicles.

How do SGLT2 inhibitors work?

SGLT2 inhibitors help people with type 2 diabetes improve their blood sugar control by preventing the kidneys from resuming glucose. While this increases the amount of glucose excreted in the urine, it can also lead to urinary tract infections. SGLT2 inhibitors are generally better known as Forxiga (dapagliflozin), Invokana (canagliflozin) and Jardiance (empagliflozin).

Fournier gangrene is a rare side effect of SGLT2 inhibitors

In the study, the researchers reviewed the reported cases of infections in patients using SGLT2 inhibitors compared to those taking so-called antiglycemics. It has been found that since the approval of SGLT2 inhibitors in 2013, 55 cases of Fournier gangrene have occurred in diabetics who are taking such drugs.

By comparison, the team found only 19 cases in patients taking antiglycaemics in the past 35 years. Knowing the relationship between the occurrence of Fournier gangrene and the use of SGLT2 inhibitors can be an important factor in the proper treatment of diabetes. However, it must be emphasized that the Fournier gangrene is a very rare side effect of these drugs, the researchers emphasize.

Do not stop taking SGLT2 inhibitors yourself

SGLT2 inhibitors have proven to be a safe and effective treatment for type 2 diabetes, and anyone taking them shouldn't worry unnecessarily or change or stop taking medications without talking to their doctor, the researchers warn. However, if people take SGLT2 inhibitors and experience unusual symptoms, including strange odor or genital swelling, fever, or unexpected pain, they should see a doctor as soon as possible. (as)

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